This document was developed under a joint project between UNICEF and The Global Coalition on Women and AIDS. It provides graphic and tabular evidence which link sexual knowledge/behaviours to the educational level among young people. It outlines three priorities that support schools in protecting girls and mitigating the impact of HIV and AIDS, which are: getting and keeping girls in school, providing life-skills based education; and protecting girls from gender-based school violence. The following are the chapters included in its contents: 1) The changing face of HIV and AIDS; 2) Girls and women under threat; 3) The power of girls' education; and 4) Call to action.