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This paper first introduces the key issues regarding orphaned and vulnerable adolescents in the time of HIV/AIDS, including the developmental needs specific to adolescents. The second chapter summarizes the limited studies and programs working primarily with adolescents orphaned due to AIDS. Following are four case studies that demonstrate different strategies for working with adolescent orphans and other youth vulnerable to HIV/AIDS, reflecting different cultural and programmatic approaches relevant to Africa, Asia, and Eastern Europe. …