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Objectives: To determine the prevalence of HIV infection, HIV risk factors, and exposure to national HIV prevention programs, and to identify factors associated with HIV infection among South African youth, aged 15–24 years. Design: A cross-sectional, nationally representative, household survey. Methods: From March to August 2003 we conducted a national survey of HIV prevalence and sexual behavior among 11 904 15–24 year olds. Multivariable models for HIV infection were restricted to sexually experienced youth. …