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Developing effective interventions to mitigate the devastation of HIV/AIDS causes among children and families requires giving careful attention to both ends of the epidemic's spectrum of impacts. It is vitally important to understand the problems on a human scale, what happens to parents, children, and orphans' guardians. But this perspective, by itself, is not adequate to guide a strategic response to these problems. It is also essential to keep in mind the magnitude and scale of the HIV/AIDS pandemic and its collective impacts.