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HIV prevention programming is increasingly taking place in school settings, which provide an expansive population of young people and offer immense potential for making a large and much-needed impact in the lives of this target group. The Presidential Initiative on AIDS Strategy for Communication to Youth (PIASCY) is an ambitious, school-based programme that has sought to address the HIV/AIDS epidemic in Uganda in a holistic manner since 2002, targeting young people, school personnel, parents, and the wider community. …