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Lack of education and an economic dependence on men are often suggested as important risk factors for HIV infection in women. The authors assessed the efficacy of a cash transfer programme for schooling to reduce the risk of sexually transmitted infections in young women. Based on their findings the authors conclude that cash transfer programmes can reduce HIV and HSV-2 infections in adolescent schoolgirls in low-income settings. Structural interventions that do not directly target sexual behaviour change can be important components of HIV prevention strategies.