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Around the world, 5 million young people are living with HIV. Most live in the Global South in countries that lack the resources to meet their needs. They face widespread stigma in a world that still often misunderstands HIV and fears or blames those who have it – and the majority of HIV-positive youth are women, placing them at an even greater societal disadvantage in many countries. This brief provides an overview of HIV-positive youth: who is infected, treatment options and challenges, needs of positive youth, stigma and programs.