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Objective: To evaluate a four-hour life-skills-based HIV/AIDS prevention curriculum among 5th grade students in rural primary schools of Hainan province. Methods: The study included two stages. Stage one (September 2006-May 2007) was a pre-post-quasi experimental design; a total of 2 413 students aged 9 to 14 years from fifth grade classes of nine primary schools completed a baseline survey (1 720 students were in the intervention group, 693 in the control group), and over 98% of them took part in a short survey. The experimental curriculum was provided to the intervention group. …