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This APCOM policy brief presents evidence on the vulnerability of young MSM, particularly with regard to HIV & AIDS. It highlights the gaps in strategic information in the region, particularly for young transgender people. It encourages countries to strengthen health promotion programmes for high-risk youth, while ensuring appropriate services for those who are HIV-positive. The brief calls on countries to engage young MSM and transgender people in national AIDS response, and to review and challenge laws criminalising sex between men.