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The interactions among religious affiliation, education, HIV knowledge, and HIV-related sexual behaviors among African church youth are poorly understood. In this sociodemographic study, 522 unmarried youth 12-28 years old in rural central Mozambique were surveyed with a structured questionnaire. Using binary logistic regression analysis, the authors used religious affiliation and education to measure influence on (1) HIV transmission and prevention knowledge and attitudes and (2) HIV-related sexual behaviors among youth. …