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Sex and relationship education (SRE) is regarded as vital to improving young people's sexual health, but a third of schools in England lacks good SRE and government guidance is outdated. The authors aimed to identify what makes SRE programmes effective, acceptable, sustainable and capable of faithful implementation. […] They identified key features of effective and acceptable SRE. Their best practice criteria can be used to evaluate existing programmes, contribute to the development of new programmes and inform consultations around statutory SRE.